重症病毒性肝炎心钠素、肾素—血管紧张素及醛固酮的测定

The Determination of the Blood Concentrations of Cardionatrin, Reninactivity, Angiotensin, Aldosterone in Patients with Viral Hepatic Failure

对26例重症型病毒性肝炎(FVH)血浆心钠素(ANF)、血浆肾素活性(PRA)、血管紧张素Ⅱ(AT-Ⅱ)及醛固酮(ALD)之检测,发现这些体液因子均有非常明显的增高。可能与FVH出现微循环障碍、电介质失衡甚而导致多器官功能衰竭(MOFS)有关。

The authors determeaed plasma concentrations of cardionatrin, reninactivity, angiotensin, aldosteron in 26 patients who were suffered from viral hepatic failure. Among them there were 5 cases of viral icterohepatitis, 6 cases of liver cirrhosis and 30 cases of normal controls. All of the 4 humoral factors raised significantly in the patients with viral hepatic failure. By statistics, their values were ()2.59, 12.5, 2.11 and 2.78 times the value of normal coutrols respectively. The causes of such raise; are very complex, probably it is due to the massive necrosis of liver, so the synthesis of the protein hydrolytic enzymes are deficient, then the plasma factors can't be destroyed regularly. There are another explanations, that the accumulation of several toxic substances in the tissue fluid may stimulate the sympathetic nerves, then excite the RAAS of under the influence of the nerves and endocrines, the secretions(the 4 factors) increased. The over concentrations of such humoral factors may of the endocause the disturbance of microcirculation and disorders of the equilibrium of the endo environment. All of these abnormal physiological changes may cause the pathogenic injure in hepatitis pts. more severely.