吴茱萸化学成分研究(英文)

Studies on the chemical constituents of Evodia rutaecarpa (Juss.) Benth.

目的 研究吴茱萸Evodiarutaecarpa [Juss.]Benth .的化学成分。方法 采用溶剂法、硅胶柱色谱和重结晶等方法进行分离纯化 ,根据化合物的理化性质和光谱数据鉴定结构。结果 从吴茱萸中分离得到 14个化合物。鉴定出其中的 10个化合物 ,分别为吴茱萸宁碱 (evodianinine ,1)、吴茱萸次碱 (rutaecarpine ,2 )、吴茱萸碱 (evodiamine,3)、吴茱萸酰胺I(wuchuyuamideI,4 )、羟基吴茱萸碱 (hydroxyevodiamine ,5 )、柠檬苦味素 (limonin ,6 )、胡萝卜苷(daucosterol,7)、三十碳酸 (triacontanoicacid ,8)、二十九烷 (nonacosane ,9)和 β 谷甾醇 (β sitosterol,10 )。 结论 通过UV ,IR ,ESI MS ,HREIMS ,1 HNMR ,1 3CNMR ,HMQC ,HMBC和NOESY分析 ,鉴定化合物 1是新化合物 。

Aim To study the chemical constituents of Evodia rutaecarpa (Juss.) Benth. Methods The crude total alkaloids were enriched by acid-base treatment and solvent extraction. Isolation and purification were carried out by silica gel column chromatography and recrystallization etc. Structural determination of the pure compounds were based on physico-chemical properties and various spectral data analysis ( 1HNMR, 13CNMR, UV, IR, 1H- 1H COSY, HMQC, HMBC, ESIMS, HREIMS, NOESY). Results Fourteen compounds were obtained from Evodia rutaecarpa, ten of them were identified as evodianinine (1), rutaecarpine (2), evodiamine (3), wuchuyuamide I (4), hydroxyevodiamine 5), limonin (6), daucosterol (7), triacontanoic acid (8), nonacosane (9) and β-sitosterol (10). Conclusion Compound 1 is a new alkaloid named evodianinine.