可降解聚合物聚己内酯体内生物相容性的实验研究

Biocompatibility evaluation of the of polycaprolactone in vitro

目的 :评价可降解聚合物聚己内酯 (PCL )的体内生物相容性 ,为构建成骨细胞 - PCL材料复合的组织工程骨的可行性提供参考依据 ,并为临床修复骨缺损提供新的人工替代材料。 方法 :Wistar大鼠 30只 ,随机分为实验组与对照组 ,实验组大鼠两侧肌内各植入 2枚 PCL样品 ,对照组大鼠两侧肌内植入 2枚医用硅橡胶样品 ,进行大体标本、组织学及透射电镜观察。结果 :PCL 界面无明显的炎性反应 ,材料与组织界面接合紧密。结论 :PCL 是一种具有良好的生物相容性、缓慢降解、无毒性、无免疫原性的材料。

Objective: To evaluate the biocompatibility of polycaprolactone in vitro. Methods: Plant PCL and silicon model (2 mm×6 mm) to the muscles on both sides of rat. By gross,histopathological and transmission electron microscope examination. Result: PCL films had a mild inflammatory reaction in the early days of planting and after 3 months the inflammation basically disappeared. PCL material possesses good biocompatibility, biodegradable. Conclusion: PCL is a kind of material with good biological compatibility,no toxin and antigen free.