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基质金属蛋白酶在鼻内翻性乳头状瘤及鼻息肉组织中的表达 被引量：1

Matrix metalloproteinases expression of nasal inverted papilloma
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摘要 目的:探讨基质金属蛋白酶 (MMP)家族成员中的 MMP- 2和 MMP- 9在鼻内翻性乳头状瘤和鼻息肉组织中的表达。方法:采用免疫组织化学方法检测 30例鼻内翻性乳头状瘤和 15例鼻息肉组织中 MMP- 2和 MMP- 9的表达。结果 :MMP- 2和 MMP- 9在细胞浆染色最强。鼻内翻性乳头状瘤组织和鼻息肉组织中 MMP- 2阳性表达率分别为 5 6 .6 7%和 4 6 .6 7% (χ2 =0 .4 0 2 ,P >0 .0 5 ) ,MMP- 9阳性表达均为 80 .0 0 %。结论:MMP家族所致的蛋白水解酶活性增高可能在鼻内翻性乳头状瘤对骨的破坏力上起主要作用。 Objective: To investigate the expression of difference MMP-2 and MMP-9 of matrix metalloproteinases in nasal inverted papilloma(NIP). Methods: 30 NIP and 15 nasal polyps (NP) were studied with immunohistochemical LSAB (Labeled Streptavidim Biotin) method. Results: The results indicated that 56.67% cases of NIP were MMP-2 positive,and 80.00% cases of NIP were MMP-9 positive. Conclusion: MMP-2 and MMP-9 may play an important role in the development of NIP.
作者 郑艳 张华 王春利 丁军
机构地区 新疆医科大学第二附属医院耳鼻咽喉科 新疆医科大学第一附属医院耳鼻咽喉科
出处 《新疆医科大学学报》 CAS 2004年第4期399-400,共2页 Journal of Xinjiang Medical University
关键词 鼻内翻性乳头状瘤 鼻息肉 金属蛋白酶 nasal inverted papilloma nasal polyps matrix metalloproteinases
分类号 R765.25 [医药卫生—耳鼻咽喉科]
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共引文献100

同被引文献19

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新疆医科大学学报
2004年 第4期

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