高血压病患者血浆白细胞介素18水平的检测与分析

Plasma levels of interleukin 18 in patients with primary hypertension

目的 :了解白细胞介素 1 8(IL- 1 8)在高血压病发病机制中的作用。方法 :采用双抗体夹心法 ELISA法对不同等级的高血压病患者和高血压病合并心力衰竭患者 35例及 30名健康者的血浆 IL- 1 8水平作了检测和比较。结果 :高血压病患者血浆 IL- 1 8水平显著高于正常对照组 (t=4.60 3,P<0 .0 0 1 ) ,并随高血压病级别的上升而升高 (P均 <0 .0 5) ;合并心力衰竭患者血浆 IL- 1 8水平显著高于无心力衰竭者 (t=2 .81 ,P<0 .0 1 )。结论 :高血压病的发生可能有 IL- 1 8参与。

Objective:To investigate the role of interleukin 18 (IL-18) in the pathogenesis of primary hypertension (PH). Methods:Plasma levels of IL-18 in 35 patients with PH and 30 health controls were measured by ELISA. Result:IL-18 contents in patients with PH were significantly higher than those in normal controls (t=4.603,P<0.001), which varied with the degree of PH (P<0.05). Furthermore, IL-18 concentrations were remarkably increased in patients with heart failure (HF) as compared with those without HF (t=2.81, P<0.01). Conclusion:IL-18 could be involved in the pathogenesis of PH.