肺炎支原体肺炎患儿血、尿α-1微球蛋白测定

Detecting of α-1 microglobulin in blood and urine in infants with mycoplasma pneumonia

目的 :探讨血、尿α 1微球蛋白检测在小儿肺炎支原体肺炎患儿肾脏损伤中的诊断意义。方法 :采用速率免疫散射比浊法和放射免疫法分别检测了 135例小儿肺炎支原体肺炎、130例其他病原所致肺炎患儿血、尿α 1微球蛋白异常率 ,并与血清肌酐异常率作对比 ;130例正常儿童作为对照。结果 :肺炎支原体肺炎组小儿指标水平均高于其他 2组 (P <0 .0 0 1)。支原体肺炎组血、尿α 1微球蛋白异常率及血肌酐异常率分别为 2 9.1%、33.5 %和 5 .5 % ,其他病原肺炎组异常率分别为 7.3%、7.1%和 3.3% ,正常对照组 0、0 .8%和 0 ,3组间比较差异均有统计学意义 (P <0 .0 1) ;结论 :血、尿α 1微球蛋白检测是反映小儿肺炎支原体肺炎早期肾损伤的一种较灵敏的指标。

Aim: To explore the diagnosable significance of α-1 microglobulin detecting for the renal injury in infants with mycoplasma pneumonia. Methods: The serum and urine α-1 microglobulin,serum creatinine of 135 infants with mycoplasma pneumonia(Group A),130 infants with other pneumonia(Group B),and 130 normal infants (Group C) were detected. Results: There were significant differences in the level and the abnormity rates of the three indexes mentioned above among the three group,and the indexes of Group A were higher than those of the other groups(P<0.01). The abnormity rates of serum and urine α-1 microglobulin in Group A were higher than that of serum creatinine (P<0.01). Conclusion: Serum and urine α-1 microglobulin may be a sensitive index to the renal injury diagnoses of mycoplasma pneumonia infants.