肺癌组织中GST-π和p53的表达及其相关性研究

A Study on the Expression and Correlation of GST-π and p53 in Human Lung Cancer

目的 探讨酸性谷胱甘肽S -转移酶 (GST -π)和p5 3蛋白在肺癌中表达的临床病理意义和相关性。方法 应用LSAB免疫组化法对 60例肺癌组织GST -π和p5 3蛋白的表达进行研究。结果 肺癌中GST -π和p5 3蛋白的阳性率分别为5 6 67%和 3 1 67%。GST -π和p5 3蛋白表达与肿瘤分化程度明显相关 ,高中分化肺癌阳性率明显高于低分化及未分化者 (P <0 0 5 )。GST -π与p5 3蛋白表达呈明显正相关 (r =0 3 75 ,P <0 0 5 ) ,p5 3蛋白阳性者中GST -π阳性率高于p5 3蛋白阴性者。结论 GST -π和p5 3蛋白异常表达可能与肺癌的发生发展有关。检测GST -π表达对预测肺癌多药耐药。

Objective To study the clinical pathological significance and relationship of placental glutathione-s-transferase(GST-π) and p53 protein expression in the tissues of human lung carcinomas. Methods The expressions of GST-π and p53 in 60 cases of lung carcinomas were detected by the LSAB immunohistochemical method. Results The positive rates of GST-π and p53 protein expression in lung carcinomas were 56 67% and 31 67% respectively. The expressions of both GST-π and p53 had obvious relationship with the differential degree of the tumors(P<0 05), and the positive rates of both GST-π and p53 in highly and medially differential lung carcinomas were significantly lower that those in poorly differential and undifferential ones. The GST-π exprssion in the lung cancers was positive correlation with p53 expression(P<0 05), and the positive rate of GST-π expression in the p53 positive lung cancers was obviouly higher than that in the p53 negative ones. Conclusion The abnormal expressions of GST-π and p53 may be related to the pathogenesis and progress of the lung carcinoma.