口服红色诺卡氏菌细胞壁骨架制剂联合化疗对恶性肿瘤患者生活质量及体质状态的影响

Effects of oral nocardia rubra cell wall skeleton preparation combined with chemotherapy on the quality of life and physical status in malignant neoplasms

目的:探讨口服红色诺卡氏菌细胞壁骨架制剂nocardiarubracellwal(skeletonpreparation,N-CWS)对患者生存期的生活质量的改善情况。方法:试验组35例采用N-CWS联合化疗,对照组30例单用化疗。对生活状态评分、疗效、缓解时间、临床受益率、T细胞亚群、NK细胞、副作用进行观察。结果:试验组生活质量评分增加(t=5.653,P<0.05),生活状态评分增加(t=4.212,P<0.05),化疗后缓解时间为(19.63±9.18)d,临床受益率为86%(30/35),NK细胞提高,而有效率、副作用、T细胞亚群变化差异无显著性意义(P>0.05)。结论:口服N-CWS能改善患者的生活质量和体质状态,患者耐受性良好。

AIM:To observe the efficacy of oral nocardia rubra cell wall skeleton preparation(N CWS) for improving patients' quality of life(QOL) in survived period. METHODS:Thirty five cases in the experimental group were treated with oral N CWS and chemotherapy,and 30 cases in the control group only with chemotherapy.Furthermore,the score of QOL,efficacy, remission time, clinical benefit rate,subset of T cells and NK cells and side effect were observed. RESULTS:The score of QOL in the experimental group was increased(t=5.653, P< 0.05),the score of life status was increased(t=4.212,P< 0.05).The clinical benefit rate was 86%(30/35),remission time after chemotherapy was(19.63±9.18) days.NK cells were higher than before. But as efficacy rate, side effect,and subset of T cells were concerned, there were no significant differences between the two groups(P >0.05). CONCLUSION:Oral N CWS can improve physical quality and QOL with good tolerance.