摘要
目的:对生物高分子复合材料羟基磷灰石(HA)/L-聚乳酸(PLLA)体内外降解进行评价。方法:将自制HA/PLLAcage放入磷酸盐缓冲液(PBS)和植入家兔背肌内降解40周,分段测定材料的黏均相对分子质量和生物力学强度。结果:材料在体内外的黏均相对分子质量和生物力学强度随时间逐渐下降,前16周下降缓慢,24周后逐渐加快,40周材料在体内外的黏均相对分子质量和力学强度下降的百分率分别是43.4%,37.4%,35.9%
AIM:To evaluate the degradation of high polymer hydroxyapatite (HA)/L polyactic acid (PLLA) in vitro and in vivo. METHODS: The self controlled HA/PLLA cages were put in phospatat buffe (PBS) and embedded in the muscles of the New Zealand rabbits' backs respectively, and the changes of viscosity average molecular weight and compressive strength of cages were estimated in 40 weeks. RESULTS:The viscosity average molecular weight and compressive strength of cages decreased follow times, the rate of degradation of polymer was slow before 16 weeks and it became fast after 24 weeks, the percentage of decreasing of the viscosity average molecular weight and compressive strength of cages was 43.4%,37.4%,35.9% and 26.02% respectively in vitro and in vivo. CONCLUSION: The high polymer biomaterial of HA/PLLA has a long degradation period, and the degradability of the polymer need a long dated evaluation.
出处
《中国临床康复》
CSCD
2004年第26期5548-5549,共2页
Chinese Journal of Clinical Rehabilitation