BAFF及其受体BAFF-R与SLE的关系
摘要
BAFF(BcellactivativingfactorbelongingtotheTNFfamily)即属TNF家族的B细胞活化因子 ,是新近发现的一个TNF家族成员。众多研究发现BAFF与B细胞的生存、增殖有密切关系 ,BAFF转基因鼠具有明显的SLE样症状。SLE病人血清中BAFF含量明显增高。本文就这方面的研究进展作一综述。
出处
《国外医学(免疫学分册)》
2004年第5期285-288,共4页
Foreign Medical Sciences(Section of Immunology Foreign Medical Sciences)
参考文献20
-
1Allman D, Lindsley RC, DeMuth W, et al. Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation[J].J Immunol,2001,167(12) :6834-6840.
-
2Schneider P, Takatsuka H, Wilson A, et al. Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen[J]. J Exp Med, 2001,194( 11 ): 1691-1697.
-
3Kayagaki N, Yan M, Seshasayee D, et al. BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2[ J]. J Immunol, 2002, 17(4):515-524.
-
4Thomson JS, Bixler SA, Qian. F et al. BAFF-R, a newly indentified TNF receptor that spectifically interacts with BAFF [J]. Science, 2001, 93(5537):2108-2111.
-
5Do RK, Chen-Kiang S. Mechanism of BLyS action in B cell immunity[J].Cytokine Growth Factor Rew, 2002,13 (1): 19-25.
-
6Craxton A, Magaletti D. Macrophage-and dendritic cell-dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF [J]. Blood, 2003,101(11) :4464-4471.
-
7Rolink AG, Melchers F. BAFFled B cells survive and thrive: roles of BAFF in B-cell development[J]. Curr Opin Immunol,2002,14(2);266-275.
-
8Laabi Y, Strasser A. Immunology Lymphocyte survival-ignorance is BLyS [J]. Science, 2000, 289 ( 5481 ): 883-884.
-
9Xu LG, Wu M, Hu J, et al. Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1[J] .J Leukoc Biol,2002,72(2) :410-416.
-
10Xu LG, Shu HB. TNFR-associated factor-3 is associated with BAFF-R and negatively regulated BAFF-R-mediated NF - kappa B activation and IL-10 production[J]. J Immnnol, 2002,169(12): 6883-6889.
-
1高会广,何凤田,李蓉芬,陈珊,唐蓓,彭家和,陈敏,周度金.人BAFF cDNA的克隆及原核表达载体的构建[J].第三军医大学学报,2003,25(6):498-500. 被引量:1
-
2孙艳,兰小鹏.DcR3与免疫系统关系的研究进展[J].现代免疫学,2004,24(4):338-340. 被引量:2
-
3吴蔚,陈民利.BAFF在自身免疫性疾病方面的研究进展[J].中国比较医学杂志,2012,22(1):79-82. 被引量:3
-
4徐海燕,邱玉华,张学光.BAFF信号的免疫调节作用[J].国外医学(免疫学分册),2004,27(5):304-306.
-
5欧子强,唐勇,向军俭,吕卫东,林婷婷.小鼠B淋巴细胞活化刺激因子可溶性片段在毕赤酵母中的表达、纯化及其生物学活性的初步鉴定[J].中国生物制品学杂志,2013,26(6):787-791.
-
6吴海涛,胡云龙,刁振宇,金丽娜,李洁,张双全.一种新免疫调节因子:B淋巴细胞刺激因子[J].中国免疫学杂志,2006,22(3):283-286.
-
7冯艳菊(摘),王林(摘).肿瘤坏死因子受体(TNFR)超家族三聚体[J].国外医学(药学分册),2006,33(4):310-310.
-
8包兆胜.Fas与FasL的分子生物学研究进展[J].生命的化学,2002,22(2):127-129. 被引量:3
-
9谢赛.免疫系统的TRAIL通路[J].中国病理生理杂志,2009,25(9):1675-1675. 被引量:1
-
10刘存仁.TNF家族成员TALL-1及其研究进展[J].生物化学与生物物理进展,2001,28(4):490-493.