人体内有机物分析及邻苯二甲酸酯含量测定

Analysis on organic compounds component and determination of phthalate acid esters in human body

目的 了解人体内有机物成分及重要有机物的污染水平 ,并评估对人群健康可能产生的危害。方法 采集 50名健康产妇静脉血 ,应用气相色谱 -质谱联用技术 (GC/MS) ,对血液中有机物进行定性检测及重要有机物的定量测定。结果 人体内共检出有机物 158种 ,检出率较高的有机物有 9-十八烯酸 (82 % )、十七烯 -(8)碳酸(66% )、邻苯二甲酸二丁酯 (62 % )、硫代 -(2 -氨基乙基 )硫酸酯 (3 4 % )、14 -β -孕激素 (2 8% )等 ,在检测出的有机物中对检出率较高、具有毒性效应的邻苯二甲酸二丁酯进行定量测定 ,其浓度为 (78 2 9± 3 4 0 1)mg/L。 结论 人体内存在有机物污染 ,部份有机物在人群体中检出率较高 ,其中检出率较高、浓度也较高的邻苯二甲酸二丁酯作为美国环境保护局 (EPA)优先控制污染物 ,具有生殖发育毒性 ,应当引起人们 (特别是育龄期妇女 )

ObjectiveTo explore components of organic chemicals and polluted levels of important organic materials in human body,evaluate its potent ial hazard on population health.MethodsThe venous blood specimens from 50 health women w ere collected.Qualitative analysis organic chemicals and quantitative detective important organic materials in venous blood by gas chromatography/mass spectrome ter(GC/MS) after extraction with hexane.Results158 kinds of organic materials were detected from all blood samples,a significantly high frequency of organic chemicals included 9 -Octadecenoic acid (82%),heptadecene-(8)-carbonic acid(66%),di-n-butyl phthalate (62%),thiosulfuric acid (H2S2O3),S-(2-aminoethyl)ester (34%),14-Bate-H-pregna ( 28%),et c.Di-n-butyl phthalate with highly checked out frequency and toxic effec t was determined quantity.ConclusionOrganic pollutants existed in human body and s ome of them were highly checked out.Di-n-butyl phthalate with highly check ed out rate and highly concentration had reproductive developmental toxicity as prority control pollution in USEPA.It would bring about a potential adverse effe ct on population health (for example reproductive toxicity).It should cause our highly attention (special child-bearing period women).