双能X线吸收法及定量CT法诊断骨质疏松症的比较研究

Dual energy X-ray absorbtion verses quantitative computed tomography for diagnosis of osteoporosis

本研究比较了双能Ｘ线吸法（ＤＸＡ）与定量ＣＴ（ＱＣＴ）在骨质疏松症诊断中的应用。对５６例健康妇女（Ｈ组）及４８例骨折后骨质疏松妇女（ＯＰ组）进行了ＤＸＡ及ＱＣＴ测量。ＤＸＡ与ＱＣＴ在Ｈ、ＯＰ组均显著相关（ｒ＝０．７５，Ｐ＜０．０００１，ｒ＝０．５８，Ｐ＜０．０００１）。Ｈ组及ＯＰ组，随年龄增长的骨减少率，ＱＣＴ较ＤＸＡ法为高。而两组中骨密度的差别，ＱＣＴ较ＤＸＡ法更大（Ｐ＜０．０５）。结论；由于ＱＣＴ可以选择性测量椎体松质骨，故可较ＤＸＡ更能很好地区分健康人与骨质疏松病人。

In this study we compared dual energy x-ray absorption (DXA) and quantitative computed tomography (QCT) in the diagnosis of osteoporosis. DXA and QCT measurements were obtained in 56 healthy (H) and 48 fractured osteoporotic (OP) women using a Hologic QDR 1000 bone densitometer and a GE 9800 scanner,respectively. DXA was significantly correlated with QCT in both the H(r=0. 75,P<0. 0001) and the OP subjects (r=0. 58,P<0. 0001 ). The rate of bone loss with age by QCT was higher than that by DXA in both normal and osteoporotic women. The difference in bone density between the H and the OP subjects was larger (P<0. 05) by QCT than by DXA does. We conclude that QCT,by selectively measuring trabecular bone,discrminates better between normal and osteoporotic women than DXA.