运动性免疫抑制的机制研究

Study on Mechanisms of Exercise-induced Immunosuppression

为进一步研究运动性免疫抑制的机制 实验方法采用对大鼠进行为期8周,每周6次,每次150min的游泳训练,测定淋巴细胞的增殖功能、细胞因子等免疫指标、血清Gln、Arg含量以及淋巴细胞凋亡的变化。结果显示:①8周大负荷训练后,大鼠血清IL-2含量和淋巴细胞转化率均显著降低,而血清sIL-2R含量却显著升高。②8周大负荷训练后,大鼠血清Gln、Arg含量以及血清GM-CSF含量显著降低,而淋巴细胞凋亡率却显著升高。结论为:①长期大负荷训练可以导致机体细胞免疫功能的显著降低;②长期大负荷的运动训练可以导致血清Gln、Arg含量的降低和外周淋巴细胞凋亡增加,可能是运动性免疫抑制的重要机制。

To further explore the mechanism of exercise-induced immunosuppression. Methods: SD rats were conducted 150 min/day, 6days/wk swimming training for 8 weeks.The immunologic indexes including lymphocytic proliferation function, serum cytokine concentration, and serum glutamine, arginine levels, and apoptosis of lymphocyte in peripheral blood were determined. Results: ① After heavy training for 8 weeks, the serum IL-2 concentration and lymphocytic proliferation function in peripheral blood decreased significantly, but the serum sIL-2 concentration increased significantly.② Serum Gln, Arg and GM-CSF contents significantly reduced. Contrarily, rate of lymphocytic apoptosis increased significantly. Conclusions:①Long-term heavy training might result in the decrease of immunologic function.②The decrease of serum Glu and Arg, and increase lymphocytic apoptosis in peripheral blood after long-term heavy exercise trainingmight be important mechanisms of sports immunosuppression.