阿托伐他汀和辛伐他汀治疗混合型老年高脂血症的疗效比较

Comparison of Effect of Atorvastatin and Simvastatin in Treatment of the Elderly with Compound Hyperlipimia

目的 :比较阿托伐他汀和辛伐他汀治疗混合型老年高脂血症的疗效及安全性。方法 :老年混合型高脂血症80例 ,随机分为二组 ,A组阿托伐他汀 10mg/d,B组辛伐他汀 10mg/d ,治疗 8周。观察治疗前后血清总胆固醇 (TC)、甘油三脂 (TG)、低密度脂蛋白胆固醇 (LDL -C)、高密度脂蛋白胆固醇 (HDL -C)的变化情况及两组不良反应发生情况。结果 :二组均能明显降低TC、LDL -C和TG水平 (P <0 .0 1)。二组比较 ,阿托伐他汀降LDL -C作用明显优于辛伐他汀 (P<0 .0 1) ,降TC和TG水平与辛伐他汀比较亦有统计学差异 (P <0 .0 5 ) ,二组不良反应均较轻微和少见。结论 :阿托伐他汀是老年人混合型高脂血症高效。

Objectve:To evaluate the efficacy and safety of atorvastatin and simvastatin in treatment of the elderly with compound hyperlipimia. Methods:Eighty cases with compound hyperlipimia were randomly divided into two groups. One is group A with atorvastatin 10mg /d and the another is group B with simvastatin 10mg /d. During therapy for 8 weeks, the levels of TC, TG, LDL-C and HDL-C in serum were examined before and after therapy and adverse reactions was also observed. Results:The levels of TC, TG and LDL-C significantly decreased for two groups (P<0.01).Compared with simvastatin, astorvastatin is more significant in reducing the levels of TC, LDL-C and TG (P<0.05). The adverse reactions for two groups are mild and rare. Conclusions. Astovastatin is a safe and effect medicine in treatment of the elderly with compound hyperlipimia.