广州市传染性非典型肺炎危险因素及传播途径

Study on risk factor and routes of transmission of SARS in Guangzhou

目的 了解SARS流行的危险因素及传播途径。方法 选择广州市经血清学检测SARS抗体阳性病例2 36例 ,SARS抗体阴性的健康人 2 0 6例 ,采用单因素和多因素Logistic回归分析方法进行比较。结果 医务人员感染SARS的危险性比非医务人员大 ,其OR值为 9 6 3(3 6 7～ 2 5 2 6 ) ,流行期间不到医院可明显降低感染的危险性 ,其OR值为 0 39(0 18～ 0 83) ,不接触动物者感染SARS的危险性亦降低 ,OR值 0 2 9(0 14～ 0 6 1)。多人同办公室或多人同厂工作可增加感染的危险性 ,其OR值分别为 4 0 5 (1 34～ 12 2 0 )和 2 4 4 3(3 92～ 15 2 32 ) ,工作场所通风不良的OR值为 2 91(1 15～ 7 37)。无麻疹、流感等疫苗按种史者可能会增加感染SARS的危险性 ,OR值为 2 0 3(0 93～ 4 4 1) ,但无显著性差异。不吸烟者的OR值为 2 4 3(0 79～ 7 4 4 ) ,但无显著性差异。结论 除与病人密切接触或近距离接触是重要传播途径外 ,工作场所人口密集和通风不良是感染SARS的危险因素。动物接触史与SARS发生有密切关系 ,支持SARS病毒来源于动物的可能性。

Objective To probe the risk factor and routes of transmission of SARS in Guangzhou.Methods 236 SARS IgG positive cases and 206 negative cases in Guangzhou were selected and the logistic regression was adopted to analyse the related factors.Results Healthcare workers and multiple persons clustered in the same office or worksplace were apt to infected the SARS virus OR =9.63,95% CI (3.67-25.26) and OR =4.05,95% CI (1.34-12.20),respectively;Having not went to hospital during the epidemic period and non-associated with animal were less likely to infect the SARS virus, OR =0.39,95% CI (0.18-0.83) and OR =0.29,95% CI (0.14-0.61),respectively;Having not injected the bacterin of measles and flu and the smokers were impressionable to the SARS virsus,though the possibility was not significant, OR =2.03,95% CI (0.93-4.41)and OR =2.43.95% CI (0.79-7.44),respectively;Conclusion Persons clustered in the same office or worksplace and badness aeration were the risk factors of infected SARS besides the closely contact with SARS patients.The history of animal contact was significantly correlated to the SARS IgG,which suggested that the SARS virus likely originated from the animals.