浙江省农村人群戊型肝炎感染状况的研究

Study on hepatitis E virus infection in rural general population in Zhejiang province

目的 调查浙江省农村地区戊型肝炎的感染情况、流行特征及牲畜的饲养情况与戊型肝炎病毒感染的关系。方法 2 0 0 3年 ,在浙江省北部农村地区以整群抽样的方法普查某行政村 85 0名 7岁以上健康人群 ,用ELISA法检测该人群中HEV -IgG ,HEV -IgM抗体水平 ,同时调查相关的危险因素。 结果 在调查的 85 0名健康人群中 ,抗HEV -IgG ,抗HEV -IgM阳性者分虽为 394例和 2 6例 ,人群总感染率分别为 4 6 35 %和 3 0 6 %。在 394例抗HEV -IgG阳性者中有男性 2 2 2例 ,女性为 172例 ,男女的感染率分别为 5 3 6 2 %和 39 4 5 % ,HEV感染和性别明显相关 (P <0 0 0 1)。戊肝感染可见于各个年龄段 ,但流行分布不平衡 ,有显著性差异 (P <0 0 0 1)。随着年龄的增长感染率有上升的趋势 ,但是到 4 5～ 5 5岁年龄组戊肝感染率保持在一个稳定水平。 2 5岁以下及以上人群的感染率分别为15 2 2 %和 5 2 88%。结论 浙江省农村地区的戊型肝炎病毒感染率明显高于国内已报道其他地区。戊型肝炎病毒感染与性别年龄显著相关 ,男性戊肝病毒感染率高于女性 ,随着年龄的增长感染率也上升 ,到一定年龄达到稳定水平。

Objective To investigate the seroprevalence,epidemiological characteristics of hepatitis E virus(HEV) infection in rural area of Zhenjiang provine and explore the association between breeding livestocks and hepatitis E virus infection.Methods Cluster sampling was used in northern rural area of Zhejiang province in 2003.In a door to door survey,850 healthy persons aged over 7 years were interviewed.Anti-HEV IgG and IgM were tested by commercial ELISA kits.Correlated risk factors were studied.Results The anti-HEV IgG and IgM prevalence were 46.35%(394/850) and 3.06%(26/850),respectively in the general population.The seropositivity rates of anti-HEV IgG in male and female were 53.62% and 39.45% respectively( P <0.001) and the anti-HEV IgM were 1.45% and 4.59% respectively( P <0.01).The antibodies increased with advancing age,but remain a stable level from the age of 45,the seropositivity rates of aged ≤25 and >25 were 15.22% and 52.88% respectively( P <0.001).Conclusion The prevalence of hepatitis E virus infection in this district was higher than any other reported districts in China.HEV infection was significantly associated with gender and age.Males were easily to contact hepatitis E virus.The prevalenc eof heaptitis E increased with age,but remained a stable level from certain age.No statistical association was met between HEV infection and the risk factors was assessed.