132例男性不育患者遗传学病因分析

Genetic analysis of 132 infertile men

目的 :对男性不育患者进行遗传学病因分析 ,并探讨其遗传效应。方法 :采取 132例男性不育患者外周血进行染色体核型分析。结果 :132例男性不育患者中 ,染色体异常 2 4例 ,染色体变异 2 2例。其中大Y 2 0例 ,4 7,XXY 18例 ,4 5 ,XY ,t(13;14 ) 3例 ,小Y和 4 6 ,XY ,inv(9)各 2例 ,4 6 ,XY ,t(9;2 2 ) 1例。结论 :染色体异常是男性不育的重要原因 ,并建议男性不育患者进行基因诊断 ,以便确诊是否属于遗传病 ,为生育提供指导 ,避免盲目治疗。

Objective:To study the genetic effect on man infertility according to their karotypes.Method:Karyotypes of 132 infertile men were analyzed by chromosome G banding and C banding methods.Results:24 various abnormal karyotypes and 22 chromosome polymorphisms were found in 132 cases, including 20 case of Yqh+, 18 cases of Klinefelter's syndrome, 3 cases of 45, XY, t(13;14); 2 cases of Yqh- and 46, XY, inv(9) each, 1 case of 46, XY, t(9;22).Conclusions:Chromosomal abnormality is an important cause in male infertility. Gene diagnosis was advised to diagnose genetic disease or not, which offer guidance on reproduction and avoid blindness therapy.