摘要
目的 :初步探讨血管生成素 2 (Ang 2 )在前列腺癌组织中的表达及其与临床分期的关系。 方法 :使用免疫组织化学S P法检测 2 2例前列腺癌及 10例正常前列腺组织中的Ang 2表达水平 ,并对照临床分期进行分析。结果 :正常前列腺组织未见Ang 2阳性染色 ;前列腺癌组织中Ang 2阳性染色 18例 ;Ang 2在许多前列腺癌细胞和癌组织中微血管内皮上呈强阳性染色 ,其阳性染色水平随前列腺癌临床分期上升而升高 (P <0 .0 5 )。结论 :Ang 2主要引起肿瘤新生血管形成 ,参与前列腺癌的发生和发展。Ang 2与前列腺癌的临床分期呈正相关。
Objective:To investigate expression of angiopoietin-2 in prostate cancer and determine its relationship with clinical stage.Methods:Twenty-two cases of prostate cancer and ten cases of normal prostate tissue were collected and assayed by immunohistochemical staining.Results:Normal prostate tissues were tested negative for Ang-2. Among the prostate cancer there were eighteen cases tested positive for Ang-2. Many tumor cells and microvascular endothelial cells show a prominent Ang-2 staining. The expression of Ang-2 increased significantly as the clinical stages increased(P< 0.05 ).Conclusions:The Ang-2 is thought to be involved in the neovascularization of prostate cancer. It may be related to the occurrence and progression of prostate cancer. Moreover, Ang-2 is regarded as a prognostic indicator of clinical stage.
出处
《临床泌尿外科杂志》
2004年第9期548-550,共3页
Journal of Clinical Urology
