VEGF、MMP-2、MMP-9在卵巢原发性与转移性癌中表达的研究

Different expressions of VEGF、MMP-2、MMP-9 in ovarian primary and secondary carcinoma

目的 :探讨VEGF、MMP 2、MMP 9在卵巢原发上皮癌、库肯勃氏瘤中的表达差异及临床病理意义。方法 :采用免疫组化S P染色技术对 83例卵巢癌 (卵巢原发癌 4 5例、库肯勃氏瘤 38例 )进行分析 ,观察VEGF、MMP 2、MMP 9在卵巢癌中的表达。结果 :VEGF在卵巢原发癌和库肯勃氏瘤组织中的表达显著高于正常卵巢组织 (P <0 .0 5 ) ;MMP 2、MMP 9在正常卵巢组织中表达缺如 ;VEGF、MMP 2、MMP 9在卵巢原发癌与库肯勃氏瘤中表达均有显著差异 (P <0 .0 5 ) ;VEGF、MMP 2、MMP 9在库肯勃氏瘤中及卵巢原发癌中 ,任意两指标阳性表达均有正相关性 (P <0 .0 5 )。结论 :VEGF、MMP 2、MMP 9在库肯勃氏瘤的形成机制中起重要作用 ,与肿瘤的浸润转移密切相关 。

Objective:To investigate the different expressions of vascular endothelial growth factor(VEGF) and metall proteinase(MMP 2、MMP 9) in ovarian primary carcinoma and secondary carcinoma.Methods:Streptavidin peroxidase immunohistochemistry was used to determine the expressions of VEGF,MMP 2,MMP 9 in 83 cases of ovarian carcinoma (45 of primary and 38 of Krukenberg tumors).Results:(1)the expression of VEGF was significantly different between primary ovarian carcinoma and Krukenberg tumors(P<0.05);(2)The expressions of MMP 2,MMP 9 in the every type of primary ovarian carcinomas was significantly different with that of Krukenberg tumors(P<0.05).Conclusion:All of VEGF、MMP 2 and MMP 9 are expressed in the primary ovarian carcinomas and Krukenberg tumors and have closely relationships with the invasion and metastasis.