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创伤性关节炎的发病机理 被引量:1

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摘要 创伤性骨关节炎(Post-traumatic Osteoarthritis)是骨关节炎(OsteoarthritisOA)的常见类型之一[1].自1743年Hunter首次报道关节软骨"一旦损伤,不可修复"以来,人们一直把关节软骨损伤作为创伤性关节炎的始动因素来研究.近年来,随着外伤、交通事故的增多,关节软骨损伤的机率增大,创伤性关节炎的发病率有增加的趋势.至今,人们对软骨损伤后的自然演变过程还不够十分了解,创伤性骨关节炎的发病机制仍不十分清楚[2].现对关节软骨损伤和损伤后软骨的变化做一综述.
出处 《中国矫形外科杂志》 CAS CSCD 2004年第18期1425-1427,共3页 Orthopedic Journal of China
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参考文献15

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同被引文献33

  • 1朱宝玉,陈琼,王万春,唐新桥,刘忠.创伤后关节软骨中MMP-3的表达及意义[J].实用骨科杂志,2006,12(1):35-38. 被引量:8
  • 2夏睿,董启榕,戴俭英,赵婷,孙辉.兔创伤性骨性关节炎软骨细胞中基质金属蛋白酶13表达增加[J].基础医学与临床,2007,27(2):202-203. 被引量:9
  • 3陈连旭,于长隆,王海军,林霖,魏学磊,傅欣,张继英.核因子-κBp65蛋白在大鼠创伤性骨关节炎中的表达[J].中国运动医学杂志,2007,26(4):427-431. 被引量:3
  • 4Xiaowei Li,Roger CH,Nicholas JA.An analytical model to study blunt impact response of the rabbit P-F joint.J Biomech Eag,1995,117:485.
  • 5Buckwalter JA.Articular cartilage injures.Clin Orthop,2002,14(2):134.
  • 6Murray MM,Zurakowsld D,Vrahas MS.The death of articular chondrocytes after iutra-articular fracture in humans.Trauma,2004,56(1):128.
  • 7Newberty WN,Garcia JJ,Mackenzie CD,et al.Analysis of acute mechanical insalt in an animal model of post-traumatic osteoarthrosis.Bannech Eng,1998,120(6):704.
  • 8Lin PM,Chen CT,Torzilli PA.Increased stromelysin-1 (MMP-3),proteoglycan degradation(3B3-and 7D4) and collagen damage in cyclically load-injured articular cartilage.Osteoarthritis Cartilage,2004,12(6):485.
  • 9Trumble T,Verheyden J.Remodeling of articular defects in an animal model.Clin Orthop,2004,423:59.
  • 10Matyas JR,Atley L,Ionescu M,et al.Analysis of cartilage biomarkers in the early phases of canine experimental osteoarthritis.Arthritis Rheum,2004,50(2):543.

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