人参须对四氯化碳致小鼠肝纤维化的保护作用

Preventive effects of Ginseng fiber on hepatic fibrosis induced by CCl _4 in mice

目的 :观察人参须对四氯化碳致小鼠肝纤维化的影响。方法 :运用皮下多次注射四氯化碳(CCl4)致小鼠慢性肝损伤模型 ,观察人参须对小鼠肝组织病理变化、血清丙氨酸氨基转移酶 (ALT GPT)、天冬氨酸氨基转移酶 (AST GOT)、总蛋白(TP)、白蛋白 (Alb)和白蛋白 球蛋白 (A G)的比值以及内脏器官重量的影响。结果 :人参须能够显著降低由CCl4引起的肝、脾重量增加及血清ALT、TP的升高 ,明显减轻CCl4引起的肝坏死病变 ,与秋水仙碱无差别。结论 :人参须对四氯化碳致小鼠肝纤维化有保护作用。

AIM: To study the effects of Ginseng fiber on hepatic fibrosis induced by CCl 4 in mice. METHODS: Forty PCR Mice were randomly divided into 4 the control group, the NS group, the colchicine group and the Ginseng fiber groups. Rats in control group were treated by daily oral gavage with vehicle. Rats in other three groups were given SC injection of 40% CCl 4 10 ml·kg -1 and treated by either daily oral gavage with vehicle, or colchicine at 0.1 ml·kg -1, or Ginseng fiber at 10 g·kg -1 for 42 d. The liver injury indexes were measured. RESULTS: Compared with control group, the serum enzymes of alanine aminotransferase (ALT), aspartic acid aminotransferase(AST) were markedly increased but serum albumin (Alb) and A/G were decreased distinctly in CCl 4 group whose liver slides also showed typical liver cirrhosis. Ginseng fiber markedly prevented CCl 4-induced increases in liver weight, serum ALT and TP. Ginseng fiber lightened the hepatic pathological necrosis resulting from CCl 4. The preventive effect of Ginseng fiber was identical to that of colchicine. CONCLUSION: Ginseng fiber can prevent hepatic fibrosis induced by CCl 4 in mice.