孕酮和孕烯醇酮硫酸盐对东莨菪碱引起的小鼠记忆损伤的保护作用(英文)

Protective effects of progesterone and pregnenolone sulfate on memory impairment mice induced by scopolamine

目的 :观察孕酮和孕烯醇酮硫酸盐对东莨菪碱引起的小鼠记忆损伤的保护作用。方法 :用东莨菪碱造成小鼠记忆损伤的模型 ,应用被动避暗试验测定潜伏期以评价记忆成绩。结果 :小鼠给予东莨菪碱 (1mg·kg-1,ip)后 ,其潜伏期显著减少 ,表明造成了明显的记忆损伤。孕酮 (1,10mg·kg-1,sc)和孕烯醇酮硫酸盐 (1mg·kg-1,sc)均可以在被动避暗试验中减轻东莨菪碱引起的记忆损伤。结论 :孕酮和孕烯醇酮硫酸盐可改善记忆损伤。

AIM: To investigate the protective effects of progesterone and pregnenolone sulfate on memory impairment mice induced by scopolamine. METHODS: Pharmacological model of amnesia in mice was induced by scopolamine. Memory result was evaluated by the step-through latency in the passive-avoidance task. RESULTS: Animals displayed marked decrease in the step-through latency after administration (scopolamine 1 mg·kg -1,ip). Progesterone (1 mg·kg -1,10 mg·kg -1,sc) and pregnenolone sulfate (1 mg·kg -1,sc) significantly decreased performance of animals in the passive-avoidance task. CONCLUSION: Progesterone and pregnenolone sulfate can ameliorate the memory deficit.