不同生长阶段长爪沙鼠血清中氧化与抗氧化物质含量变化

Changes of SOD, MDA and GSH-Px in Sera of Monglian Gerbils

目的 探讨不同生长阶段长爪沙鼠血清中氧化与抗氧作用机制。方法 选择 1月龄、3月龄、2 4月龄的长爪沙鼠各 16只 (雌雄各半 ) ,测定长爪沙鼠血清中超氧化物歧化酶 (SOD)、丙二醛 (MDA)、谷胱甘肽过氧化物酶 (GsH -Px)。结果 丙二醛 (MDA)在 3月龄最低 ,谷胱甘肽过氧化物酶 (GsH -Px)在 3月龄最高 ;超氧化物歧化酶 (SOD)随着长爪沙鼠的月龄增长而升高。结论 在长爪沙鼠生长过程中谷胱甘肽过氧化物酶 (GsH -Px)的含量变化与丙二醛 (MDA)含量变化有直接关系 ,而超氧化物歧化酶 (SOD)含量变化与MDA含量变化没有直接关系。

Objective To study the changes of SOD, MDA and GSH-Px in sera of Monglian gerbils.Methods The gerbils at the age of 1 month, 3 months and 24 months were used in the experiment, and the sera were collected for determining the SOD,MDA and GSH-Px. Results At the age of 3 months, MDA was the lowest, but GSH-Px was the highest, while the SOD was ascending with growing. Conclusion The changes of GSH-Px showed the direct relation to MDA, while the changes of the SOD was irrespective to the changes of MDA.