多药耐药性P-糖蛋白在药物肠道吸收中的作用

Key role of the multidrug resistance P-glycoprotein in the intestinal absorption of drugs

目的综述近五年来多药耐药性P 糖蛋白作用于药物肠道吸收过程的研究进展。方法在查阅文献的基础上介绍了P 糖蛋白的分子结构、作用机制及其底物、抑制剂和诱导剂 ,并阐明P 糖蛋白对药物肠道吸收的作用及其所引起的临床上药物相互作用。结果与结论P 糖蛋白积极参与药物肠道吸收过程 ,充分了解这一点有助于合理设计药物制剂处方 ,提高药物生物利用度 。

Objective To review the development of the key role of P-glycoprotein (P-gp) in the intestinal absorption of drugs during the past five years.Methods The molecule structure,action mechanism and sustrates,inhibitors or inducers of P-gp were introduced.The key role of P-gp in the intestinal absorption of drugs was illuminated.Results and Conclusions P-glycoprotein plays a key role in the intestinal absorption of drugs.