雷贝拉唑与奥美拉唑三联疗法治疗十二指肠球部溃疡的对比研究

A randomized,controlled study:Rabeprazole-based triple therapy vs.omeprazole-based triple therapy for the efficacy on healing of duodenal ulcer

目的 :通过与奥美拉唑比较 ,观察雷贝拉唑三联疗法治疗十二指肠球部溃疡的疗效。方法 :5 3例患者随机分为两组 ,分别给予以雷贝拉唑 (RAC)和奥美拉唑 (OAC)为主的三联疗法 ,用药结束后复查胃镜并检测 Hp。同时于用药后 1d、2 d、3d、7d、14 d对临床症状进行评估。结果 :4 7例患者完成全部治疗方案。溃疡愈合率 :RAC组为 92 .3% ,OAC组为 76 .2 % ,RAC组高于 OAC组 ,两组之间差异有显著性 (P<0 .0 5 )。 Hp清除率 :RAC组为 85 .4 % ,OAC组为 76 .2 % ,两组之间差异无显著性。两组均能有效改善症状。结论 :两组治疗方案均能有效清除 Hp和缓解症状 ,RAC组溃疡愈合率较

Objective:To compare two different regimens of rabeprazole-based triple therapy vs.omeprazole-based triple therapy for the efficacy on healing of duodenal ulcer.Methods:53 patients were assigned to receive one of the two regimens:RAC group or OAC group.The relivees of the symptoms were also evaluated on 1st,2nd,3rd,7th,14th day after the treatment.Results:47 patients completed the trial.The ulcer healing rates in RAC group and OAC group were 92.3 % and 76.2 %。The difference between the two groups was statistically signuificant (P<0.05).The eradication rates of Hp and the relieves of the symptoms between groups both was no significant difference.Conclutions:Both two groups may eradicate Hp,can improve the symptoms of duodenal ulcer patients effectively.The ulcer healing rate in RAC group was higher than in group OAC.