160例白塞氏病临床分析

Clinical Analysis on 160 Cases of Behcet Disease

目的 通过对160例患者的观察,了解白塞氏病的发病特点、发展及演变规律及内脏器官的损害特征,为诊断、治疗提供临床依据。方法 根据1989年国际白塞氏病讨论会提出的诊断标准,对160例发病年龄、病程、诱发因素、各系统的损害、各部位的病变情况、实验室相关检查的指标等采用统计学方法进行分析比较。结果 除口腔、生殖器、眼睛、皮肤的病变主症外,有45.66%的病例分别累及关节、心血管、消化道、神经系统、肺肾与附睾等。临床表现多种多样,发病有急缓之分,有的症状典型,有的以局部损害为主,有的呈隐匿性发作,有的直接损害内脏。结论 白塞氏病在急性活动期外周血白细胞往往升高,血沉增高,血液粘稠度增高,应注重免疫复合物的检测。采用中医清热解毒、化湿除毒、活血化瘀、养阴通络、健脾化湿等治疗,经临床观察有较好的疗效。

Objective By clinical observation and analysis to 160 cases, we want to find out and apprehend its trait and rule of development and evolvement, include damaging character in the purtenance, so that these can offer clinical gist for diagnosis and therapy. Method According to the diagnostic criterion instituted in international colloquium for Behcet disease in 1989, we adopt statistical analysis and disposal to compare the 160 cases, including age, course of diseases, derivational factor, damage of apiece system, pathological changes of apiece part and examination of lab. Results The familiar symptom of Behcet disease is ulceration in the nonnasality and genitalia and the damage of skin and eyes. Arthrosis, cordis vas, alimentary canal, nerve system, lung, kidney and spermary may be aggrieved in 45.66% of cases, so its clinical representation is manifold. Some person take on the typical symptom in the nonnasality, eyes and genitalia;some person take on that the symptom is taken bad in certain part, then the symptom of other's part arises in the course of outbreak and remittance;some typical symptom is perfectibility, including nonnasality, eyes and genitalia and skin, but some people's symptom is no perfectibility, only take place in two part of clay;some people take on that partial damage is primary and systemic symptom secondary;some people' diease is dormant, but the other people's disease is rapid and can damage viscus direct. Conclusion We should pay attention to the clinical representation and characteristic. There are elevatory about leucocyte and blood sedimentation rate and blood glutinous degree in acute course, so we should observe the examination of immune compound. Herbalist doctor adopts the means of qingrejiedu or huashichudu or huoxuehuayu or yangyintongluo or jianpihuashi to treat this disease and its effect is satisfying.