氯氮平治疗前后精神分裂症患者血浆及脑脊液中IL-6的变化

Changes of IL-6 in plasma and cerebrospinal fluid of schizophrenics with clozapine.

目的 研究氯氮平治疗精神分裂症前后患者血浆及脑脊液中IL 6的变化。方法 随机选取 30例住院患者为实验组 ,均符合《中国精神障碍分类与诊断标准》第 3版精神分裂症偏执型诊断标准 ,入组后单用氯氮平治疗 ;选取 2 0例健康志愿者作为对照组。采用酶联免疫吸附法测定对照组和实验组血浆及脑脊液中IL 6的浓度 ,并进行组间比较。结果 治疗前实验组血浆及脑脊液IL 6水平较对照组显著增高 ,两组比较有显著性差异 (P <0 .0 5 ) ;实验组治疗 6w后 ,IL 6水平较对照组显著增高 (P <0 .0 5 ) ;实验组症状基本缓解后血浆IL 6与治疗前比较无显著差异 (P >0 .0 5 )。结论 IL 6具有免疫增强作用 ,实验组血浆与脑脊液IL 6水平异常增高 ,提示精神分裂症患者存在免疫功能紊乱 。

Objective To study the changes of interleukin-6(IL-6) in the plasma and cerebrospinal fluid(CSF) of schizophrenics with clozapine. Methods 30 in-patients who met the criteria for paranoid schizophrenia in the CCMD-3 were randomly selected as research group and 20 healthy volunteers as control group. IL-6 levels of plasma and CSF were determined using the ELISA and inter-group comparisons conducted. Results Before treatment, IL-6 levels of plasma and the CSF were significantly higher in the research group than in the control group and inter-group comparisons showed obvious difference(P<0.05); after 6 week treatment, the IL-6 levels were significantly higher in the research group than in the control group(P<0.05); after symptoms' remission by and large, plasma IL-6 had no significant difference from pre-treatment in the research group(P>0.05). Conclusion The IL-6 has function of developing immunity, the abnormal increase of IL-6 levels suggests that schizophrenics have immunologic dysfunction which may be one of pathophysiologic mechanisms of disorders of mental activity.