奎硫平与氯氮平对精神分裂症患者生活质量影响的对照研究

Comparative study of effects of quetiapine and clozapine on quality of lift of schizophrenics

目的 探讨奎硫平与氯氮平对精神分裂症患者生活质量的影响。方法 随机将入组的 6 3例患者分为奎硫平治疗组31例 ,剂量为 2 0 0～ 5 0 0mg·d-1,平均 310 .15± 98.33mg·d-1;氯氮平治疗组 32例 ,剂量为 2 0 0～ 6 0 0mg·d-1,平均 380 .4 5±90 .16mg·d-1。应用阳性与阴性症状量表 (PANSS)、生活质量综合评定问卷 (GQOLI 74 )分别于治疗前后评估患者的生活质量与疗效。结果 治疗 3mo后 ,两组患者的PANSS总分、阳性因子、阴性因子评分与治疗前比较均有极显著性差异 (P <0 .0 1) ,两组间PANS总分、阳性因子、阴性因子评分均无显著性差异 (P >0 .0 5 )。奎硫平组躯体健康维度、社会功能维度得分高于氯氮平组 ,差异均有显著性 (P <0 .0 5 )。结论 奎硫平、氯氮平对精神分裂症的疗效相当 。

Objective To explore the effects of quetiapine and clozapine on life's quality of schizophrenics. Methods 63 patients were randomly divided into quetiapine group(n=31,mean dose 310.15±98.33mg/d) and clozapine group(n=32, mean dose 380.45±90.16mg/d).The quality of life and curative effect's were assessed with the GQOLI-74 and PANSS before and after treatment respectively. Results After 3 month treatment, scores of PANSS of both the 2 groups were significantly decreased compared with pre-treatment(P<0.01) and had no difference between the 2 groups(P>05). Scores of somatic health and social function were higher in the quetiapine group than in the clozapine group, which showed significant difference(P<0.05). Conclusion The curative effects of the two drugs are corresponding, but quttiapine is better in the improvement of life's quality than clozapine.