摘要
为探讨肺动脉高压在高盐负荷所致肉鸡腹水综合征发生发展的作用。将160只AA商品代肉仔鸡常规饲养至7日龄,随机分成对照组和试验组(饮水中添加0.30%氯化钠),分别于处理后1、2、3、4、5、6周,每组随机抽取8只鸡,利用右心导管法测定平均肺动脉压(mPAP),用温氏法检测红细胞压积(PCV),同时测定腹水心脏指数(AHI),统计腹水发生率。结果表明:(1)高盐负荷诱发肉鸡肺动脉高压,高盐处理1周试验组肉鸡肺动脉压升高为2.91±0.29kPa,显著高于对照组2.18±0.40kPa(P<0.05);并在整个处理期间持续升高,均显著(P<0.05)或极显著(P<0.01)地高于对照组;(2)高盐负荷诱发肉鸡AS,整个试验期间试验组的累计腹水发生率(16.3%)极显著高于对照组(2.5%)(P<0.01);(3)自分组后1周试验组的红细胞压积显著(P<0.05)或极显著(P<0.01)高于对照组,且与mPAP极显著相关(15~50日龄,r=0.612,P<0.01);(4)高盐负荷诱发肉鸡右心肥大,处理后2周试验组的AHI显著增高(P<0.05),与mPAP显著相关;并在整个处理期间相关程度逐渐密切(22日龄,r=0.532,P<0.05;50日龄,r=0.756,P<0.01)。这些结果说明肺动脉高压是高盐负荷所致肉鸡AS的中心环节,并且与右心肥大密切相关。
160 commercial 8 days old male broilers were randomly divided into control and experimental groups. Experimental group was treated with 0.30% NaCl in their drinking water from 8 to 50 days old. After 1,2,3,4,5,6 weeks, 8 birds were randomly taken from each group for measuring the mean pulmonary artery pressure (mPAP), the packed cell volume (PCV) and the ascites heart index (AHI) .The results were as follows:(1) The pulmonary hypertension was induced by excess salt from drinking water in broilers. From 15 to 50 days of age, the mPAP of experimental group were significantly higher than that of control group (P<0.05). (2) The incidence of ascites in experimental group was significantly higher than that of control group (P<0.01). (3) The PCV of experimental group were significantly elevated (P<0.05),and significantly correlated with mPAP (15~50 d,r=0.612, P<0.01). (4) The excess salt in drinking water could induce right ventricular hypertrophy. These data indicated that the excess salt in the drinking water induce the pulmonary hypertension that play an important role in the pathogenesis of AS in broiler chickens,and PH could induce right ventricular hypertrophy.
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
2004年第5期575-579,共5页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
国家自然科学基金资助项目(30070567
30371063)