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乙肝病毒和化学致癌物致肝细胞癌变的研究进展 被引量：8

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摘要 肝细胞癌(hepatocellular carcinoma,HCC)是原发性癌的主要形式,也是世界上发病率最高的恶性肿瘤之一.据估计全世界每年新认HCC病例大约为437 000,在常见的癌症中排名第五(占所有新发癌症病例的5%).HCC的发病率在不同的地区有很大的差异,如中国江苏的启东、广西扶绥等均为肝癌高发区,世界范围内荷兰发病率最低[1].HCC的发生是一个多阶段、多因素的病理过程.乙型肝炎病毒(hepatitis B virus,HBV)感染和黄曲霉毒素的暴露被认为是HCC发生的两个重要因素.流行病学资料已经显示受乙肝病毒感染的患者,HCC发生的危险性将提高100倍[2].除了HBV感染外,其他因素如丙肝病毒(hepatitis C virus,HCV)的慢性感染,酗酒和吸烟,抗氧化类维生素和硒摄入不足,高剂量摄入铁,长期摄入无机砷,暴露于二氧化钍和氯乙烯等都是HCC的环境危险因素.本文就HBV和化学致癌物的致肝癌作用研究进展作一综述.
作者 张豪 孙桂菊
机构地区 东南大学公共卫生学院
出处 《肿瘤》 CAS CSCD 北大核心 2004年第5期509-511,共3页 Tumor
关键词 肝肿瘤 癌 肝细胞 乙型肝炎病毒 黄曲霉毒素类 致癌物
分类号 R735.7 [医药卫生—肿瘤] R730.231 [医药卫生—肿瘤]
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参考文献25

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二级参考文献12

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共引文献13

同被引文献104

引证文献8

二级引证文献28

肿瘤
2004年 第5期

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