中药喘敷灵三伏天穴位贴敷防治缓解期小儿哮喘的临床研究

Clinical Study on Effect of Acupoint Sticking of Chuanfuling in Dog-Days in Preventing and Treating Children Asthma in Remission Stage

目的探讨喘敷灵三伏天穴位贴敷防治缓解期小儿哮喘的疗效及作用机制。方法 90例患儿分为 3组 ,即治疗组 (30例 ,给予中药喘敷灵三伏天穴位贴敷 )、西药组 (30例 ,用西药普米克吸入 ,疗程 1年 )和对照组 (30例 ,在缓解期不给予任何处理药 ) ,观察治疗前后临床疗效和血清体液免疫 (IgE、IgA、IgG)、细胞免疫 (Eos、IL 4、IFN γ)指标的变化。结果治疗组治疗后体液免疫和细胞免疫指标与治疗前比较均有改善 ,差异有显著性 (P <0 0 5或P <0 0 1) ,且优于对照组 (P <0 0 5或P <0 0 1) ;体液免疫中IgA、IgG优于西药组 (P <0 0 5 )。西药组治疗后体液免疫中IgE和细胞免疫诸指标与治疗前比较均有改善 ,差异有显著性 (P <0 0 5或P <0 0 1) ,且优于对照组 (P <0 0 5或P <0 0 1)。两治疗组治疗后比较 ,IL 4水平西药组优于治疗组 (P <0 0 5 )。结论中药喘敷灵三伏天穴位贴敷可显著改善患儿细胞免疫和体液免疫紊乱状态 。

ObjectiveTo explore the effect and mechanism of acupoint sticking of Chuanfuling (CFL) in dog-days (the hottest periods of the year) in preventing and treating children asthma in remission stage. MethodsNinety patients were divided into three groups, 30 in each. Patients in the CFL group were treated with CFL sticking, in the Western medicine (WM) group treated with Pulmicort inhalation, and in the control group was untreated. The clinical effect and indexes of humoral immunity (IgE, IgA, IgG) and cellular immunity (Eos, IL-4, IFN-γ) before and after treatment were observed. ResultsAfter treatment in the CFL group all the immune parameters were significantly improved (P<0 05 or P<0 01), all were better than those in the control group (P<0 05 or P<0 01), and the effect on IgA and IgG was better than that in the WM group. In the WM group after treatment, improvement was shown on the IgE and cellular immune parameters with signifian difference (P<0 05 or P<0 01), better than those in the control group (P<0 05 or P<0 01). Besides, significant difference was shown in comparing IL-4 level between the WM group and the CFL group (P<0 05). ConclusionCFL sticking in dog-days could significantly improve the immune function in children with asthma to alleviate and control the attack.