成年Graves病患者焦虑状态的相关因素分析

Anxiety and the Risk Factors in Graves’ Disease

目的 :研究成年格雷夫斯病 (Graves病 ,GD)患者的焦虑水平及相关危险因素。方法 :收集我院 2 0 0 0 7～ 2 0 0 3 4期间在门诊就诊或住院的 948名成年GD患者流行病学一般资料 ,同时对患者进行家庭功能、生活应激事件及焦虑评定 ,SPSS10 0建立数据库 ,并用描述性统计分析对GD患者焦虑水平进行分析 ;Logistic回归分析确定GD焦虑发生的危险因素。结果 :GD患者伴焦虑状态者占 61 1% ,男性 5 1 9% ,女性 64 1% ,性别之间比较差异有统计学显著性 ( χ2 =6 4,P <0 0 1) ,焦虑患者多在 3 0～ 45岁之间。受教育程度低、低经济收入的GD人群是GD患者焦虑的高发人群 ;农民、机关干部、医务人员相对其他职业的检出率为高。年龄、甲亢性眼病 (GO)、甲状腺体积、游离T3(FT3)及生活应激事件为GD患者并焦虑的危险因素 ;促甲状腺素 (TSH)、经济情况和家庭功能为GD患者并焦虑的保护因素。结论 :GD患者并焦虑的发病率较正常人群检出率高且有性别差异 ,中年人、低受教育程度、低经济收入GD人群是焦虑的高发人群 ,年龄、GO、甲状腺体积、FT3及生活应激事件是GD患者焦虑状态的危险因素 ,TSH、经济情况和家庭功能是GD并焦虑的保护因素。

Objective: To investigate the prevalence, the risk factors of anxiety in adults with Graves' disease.Methods:948 GD patients in Qilu hospital were investigated with Smikstein APGER Family Function Item, the Stress Life Events and the Zung Anxiety Scale. Meanwhile the function and the cubage of thyroid glad of every GD patients were measured.Results:579 people presented anxiety (579/938, 61.1%) with significant difference in sex, and mainly were 30～45 years old. Occupation, age, thyroid goiter, FT_3 and life events were risk factors, while TSH, incomes and family function were protective factors.Conclusion:The prevalence of anxiety in GD was higher than that of general population.