血清新蝶呤与急性冠状动脉综合征之间的关系

Relationship Between Serum Neopterin Level and Acute Coronary Syndrome

目的 :探讨急性冠状动脉综合征 (ACS)患者血清新蝶呤浓度的变化。方法 :对 4 7例ACS患者 ,其中急性心肌梗死 (AMI) 2 4例 ,不稳定型心绞痛 (UAP) 2 3例和 30例稳定型心绞痛 (SAP)患者 ,以酶联免疫法测定其血清新蝶呤水平 ,所有患者均为接受冠状动脉造影。结果 :血清新蝶呤浓度 ,在ACS病人中 ,AMI组 (1 1 88±3 0 9)nmol/L和UAP组 (9 85± 2 2 7)nmol/L ,均显著高于稳定型心绞痛患者的水平 (8 2 0± 1 5 2 )nmol/L ,(P <0 .0 0 0 1 ,P <0 .0 1 )同为ACS病人 ,AMI组与UAP之间其血清新蝶呤水平有显著差异 (P <0 .0 5 )。ACS的血清新喋呤水平与其不稳定斑块病变的数量有明显相关性。结果 :ACS病人血清新蝶呤浓度显著升高 。

Objective To explore the changes of serum neopterin levels in patients with acute coronary syndrome (ACS). Methods Serum neopterin levels were measured with ELISA in 47 patients with ACS including 24 cases of acute myocardial infarction(AMI) and 23 cases of unstable angina pectoris (UAP) and 30 patients with stable angina pectoris (SAP). All subjects had undergone coronary arterial angiography (CAG). Results Serum neopterin levels in the AMI group (11.88±3.09nmol/L) and UAP group (9.85±2.27nmol/L) were significantly higher than those in the SAP patients (8.20±1.52nmol/L) ( P <0.01, P <0.01). Differences between the of AMI group and UAP group were also singificant ( P <0.05). The levels of neopterin in ACS patients were correlated to the amount of unstable plaques shown in the CAG. Conclusion Serum neopterin levels were significantly elevated in patients with ACS and could be taken as an inflammatory marker for the instability of the atheromatous plaques.