利培酮与氯丙嗪治疗儿童精神分裂症的对照研究

Comparison study of childhood schizophrenia treated with risperidone and chlorpromazine

目的比较利培酮与氯丙嗪对儿童精神分裂症的疗效及副作用。方法对 6 0例儿童精神分裂症患者随机分为两组 ,分别给予利培酮、氯丙嗪治疗 8周 ,于治疗前和治疗后 2、4、6、8周末进行BPRS评分和TESS评价疗效和副反应。结果利培酮和氯丙嗪之间疗效差异无显著性 ,利培酮组有效率为 80 %、氯丙嗪组为 82 %。利培酮的副作用主要为失眠 ,体重增加 ,氯丙嗪嗜睡及锥体外系反应较重。结论两种药物对儿童精神分裂症均有确切疗效 ,利培酮较安全。

Objective To study the effective and safe treatment of childhood schizophrenia. Methods 60 cases with childhood schizophrenia were randomly divided into experiment (risperidone) group and control (chlorpromazine) group. EBPRS and TESS scales were used to measure effectiveness and safety before treatment and at the end of 2, 4, 6 and 8 weeks respectively. Results There was no significant difference in effectiveness between two groups. The improvement rate of risperidone group and chlorpromazine group were 80% and 82% respectively. The main side-effects in risperidone group were insomnia and increase weight, in chlorpromazine group drowsiness and EPS. Conclusion Risperidone and chlorpromazine were effective on childhood schizophrenia.