交替联合用药治疗绝经后骨质松症及70岁以下老年骨质疏松症临床研究

Clinical study of treatment of postmenopausal osteoporosis and senile osteoporosis(below the age of 70)with alternative and combined use of drugs

目的 观察交替应用降钙素 (鲑鱼降钙素 )与二膦酸盐类药物 (固邦 )同时加用钙剂与活性维生素D(海卡洛 )及适当运动 ,治疗绝经后骨质松症及 70岁以下组老年骨质疏松症的疗效。方法 1 0 3例绝经后骨质疏松症及 70岁以下老年性骨质疏松症患者用降钙素 1～ 3个月 ,同时服用钙剂 ,活性维生素D ,然后停用 1～ 2个月后 ,改服二膦酸盐 3～ 5个月 ,此期间同时服用钙剂及活性维生素D ,并适当运动 ,再停药 1～ 2个月 ,如此一个周期 ,按上述程序重复循环治疗。结果 通过 1 5～ 3年重复程序治疗 ,骨痛症状明显缓解 ,有效率高达 80 %。骨密度 (BMD)值有增高趋势 ,其中腰椎BMD值增加明显为 8 0 % (P <0 0 5 ) ,双髋部平均BMD值增高 6 2 % (P <0 0 5 )骨折率逐年下降。结论 交替联合用降钙素与二膦酸盐类药物同时加用钙剂与活性维生素D治疗绝经后骨质疏松症及 70岁以下老年骨质疏松症 ,能有效的改善骨痛 ,同时BMD值有明显增高趋势 ,降低骨折发生率。

Objective To study the result of therapy of postmenopausal osteoporosis and senile osteoporosis(below the age of 70) with alternative use of Salcatonin and Bisphosphonate and Calcium and Vitamin D 3 and proper sports at the same time.Method 103 cases of postmenopausal osteoporosis and senile osteoporosis (below the age of 70) were treated with Salcatonin for 1～3 months and given Calcium and Vitamin D 3 at the same time.After 1～2months,had Bisphosphonate(Alendronate) for 3～5 months.At meantime had Calcium and Vitamin D 3 and proper sports.And then 1～2 months’ rest.This circle was repeated.Results After 1.5～3 years’ repeated therapy circle,bone pain was obviously relived,effective rate was up to 80%.BMD was obviously improved.BMD of lumber vertebra was increased by 8.0%(P<0.05).BMD of hip was increased by 6.2%(P<0.05).Fracture rate dropped yearly.Conclusion alternative use of Salcatonin and Bisphosphonate and the use of Calcium and Vitamin D 3 at the same time for treatment of postmenopausal osteoporosis and senile osteoporosis (below the age of 70) can relieve bone pain,reduce fracture rate and elevate BMD efficiently.