1Gazdar AF, Lam S, Wistuba Ⅱ. Molecular and cytologic techniques of early detection [ M ]. Lung Cancer:principles and practice[M]. 2000. 407 -424.
2Zochbauer-Müller S, Fong KM, Maitra A, et al. 5 ' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer [J]. Cancer Res, 2001,61(9):3581 -3585.
3Esteller M, Sanchez-Cespedes M, Rose11 R, et al. Detection of aberrant promoter hypermethylation of tumor suppressor gene in serum DNA from non-small cell lung cancer patients[J]. Cancer Res, 1999,59(1) :67 -70.
4Belinsky SA,Nikula KJ,Palmisano WA,et al. Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis[J]. Proc Natl Acad Sci U S A,1998,95 (20): 11891 - 11896.
8Ikehara M, Oshita F, Kameda Y, et al. Expression of surviving correlated with vessel invasion is a marker of poor prognosis in small adenocarcinoma of the lung[J]. Oncol Rep,2002,9 (4):835 - 838.
9Chen y, Sato M, Eujimura S,et al. Expression of bcl-2,bax and P53 proteins in carcinogenesis of squamous cell lung cancer[J].Anticancer Res, 1999,19(2B) :1351 -1356.
10Sai jo Y, Sato G, Usui K, et al. Expression of nuclular protein p120 predicts poor prognosis in patients with stage Ⅰ lung adenocarcinoma[ J]. Ann Oncol,2001,12(8) :1121 - 1125.
2[1]He XH,Di YJ,Li JJ,et al. Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism [J]. Biochemical ＆ Biophysical Research Communications,2002,297(3):528- 536.
3[2]Sambrook J,Fritsch EF,Maniatis T,et al. Molecular Cloning (A laboratory manual)[M].second ed.,Cold Spring Harbor Laboratory Press,1989: 888- 898.
4[3]Komlosh A,Volohonsky G,Porat N,et al. Gamma-glutamyl transpeptidase and glutathione biosynthesis in non-tumorigenic and tumorigenic rat liver oval cell lines [J]. Carcinogenesis,2001,22(12):2009- 2016.
5[4]Huang ZZ,Chen CJ,Zeng ZH,et al. Mechanism and significance of increased glutathione level in human hepatocellular carcinoma and liver regeneration [J]. FASEB J,2001,15:19- 21.
6[5]Miyagishi,Taira K. U6 promoter-driven siRNA with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells[J].Nature Biotechnology,2002,20(5):497- 500.
7[6]Sui G,Soohoo C,Affar EB,et al. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells [J]. Proc Natl Acad Sci USA,2002,99(8):5515- 5520.
8[7]Brummelkamp TR,Bernards R,Agami R. A system for stable expression of short interfering RNAi in mammalian cells [J]. Science,2002,296:550- 553.
9[8]Dohlman HG,Thorner J,Caron MG,et al. Model systems for the study of seven-transmembrane-segment receptors [J]. Annu Rev Biochem,1991,60:653- 688.
10[9]Aplin AE,Howe A,Alanari SK,et al. Signal transduction and signal modulation by cell adhesion receptors:The role of Integrins, Cadherins, Immunoglobin-cell Adhesion Molecules and Selectins [J]. Pharmacological Reviews,1998,50(2):197- 263.
8Ambrosini G,Adida C,Altieri D C. A novel anti-apoptosis gene,survivin, expressed in cancer and lymphoma[J]. Nat Med, 1997,3 ( 8 ) :917-921.
9Hauser H P,Bardoff M,Pyrowolakis G,et al. A giant ubiquitin-conjuga-ting enzyme related to IAP apoptosis inhibitors[J]. J Cell Biol. 1998, 141 (6):1415.
10Suzuki A,Ito T,Kawano H,et al. Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death[J]. Oncogene, 2000,19( 10):1346-1553.
