舒喘灵、酮替芬治疗小儿咳嗽变异性哮喘80例疗效观察

The clinical observation of albuterol sulphate and ketotifen treating eighty children with cough variant asthma

目的:观察舒喘灵和酮替芬对小儿咳嗽变异性哮喘的疗效。方法:80例咳嗽变异性哮喘患儿随机分为治疗组和对照组两组,治疗组50例接受舒喘灵和酮替芬治疗,对照组30例接受氨茶碱和扑尔敏治疗,观察各组治疗效果。结果:治疗组有效率96.0%,明显高于对照组76.6%,两组疗效相比有显著性差异χ2=5.22,P<0.05;治疗组复发率2.0%明显低于对照组20.0%,两组复发率相比具有显著性差异χ2=5.52,P<0.025。结论:酮替芬和舒喘灵治疗小儿咳嗽变异性哮喘疗效好,副作用少,复发率低,可以作为治疗此病的常规药物。

Objective To observe the efficacy of albuterol sulphate and ketotifen in cough variant asthmatic children. Method 80 cases were randomly divided into two groups: one group(n=50) were received with albuterol sulphate and ketotifen treatment;the other group(n=30) were treated with aminophylline and chlortrimeton as control. Results The effective rate of observed group was 96.0%, much higher than that of control group,ie 76.6%, and a significant difference was found between these two groups(χ2 =5.22,P<0.05).The relapse rate of observed group was 2.0%,significantly lower than that of control group,ie 20.0%, and a obvious difference was found between these two groups(χ2 =5.52,P<0.0025). Conclusion Albuterol sulphate and ketotifen exhibited better efficacy, fewer side effect and lower relapse rate, so can be applied to treating cough variant asthma in children as regular therapeutic drugs.