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阿司匹林诱发哮喘的流行情况:系统性综述及临床意义 被引量:3

Systematic review of prevalence of aspirin induced asthma and its implications for clinical practice
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摘要 目的 对阿司匹林诱发哮喘流行情况及相关综合征进行再评估。 资料来源 以下数据库:Biosis,SciSearch(1990-2002年3月),Embase(1974-2002年3月),Medline(1966-2002年3月),Toxline,Derwent DrugFile(1964-2002年3月),学术会议论文索引,国际药学摘要,药学在线(1978-2002年3月)。 选择标准 研究类型,患者人群,评价结果的方法。综述仅限于非处方止痛剂的呼吸道反应。 结果 与文献记载的阿司匹林诱发哮喘的发生率(成人3%,95%可信区间2%-4%,儿童2%,1%-3%)相比,口服激发试验的阳性率(成人21%,14%-29%,儿童5%,0-4%)最高。大多数阿司匹林诱发哮喘患者对非处方非甾体抗炎药(NSAIDs)存在着交叉过敏:布洛芬,98%;萘普生,100%;双氯芬酸,93%。而只有7%的人对扑热息痛交叉过敏。 结论 成人阿司匹林诱发哮喘的患病率比过去提出的要高。因此,当临床需要应用阿司匹林或某种非甾体抗炎药(NSAIDs)而不能肯定其安全性时,应做口服激发试验。
出处 《英国医学杂志中文版》 2004年第4期213-216,共4页 The BMJ Chinese Edition
基金 CJ and LH are clinicians working partly in public hospital and private practice and in a research institute that receives funding from government bequests and many industry sources. Neither is directly funded by any manufacturer of non-steroidal anti-i
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