摘要
应用傅里叶变换红外光谱 (FTIR)法对 184例不同病理状态的胃镜下活检组织样品进行检测和分析 ,结果表明 ,慢性浅表性胃炎的基本谱图特征包括 :较强的酰胺Ⅱ带 ;14 6 0cm-1处的峰强高于 14 0 0cm-1处的峰强。典型的胃癌组织的谱图特征包括 :较低的酰胺Ⅱ带 ;14 6 0cm-1处的峰强低于 14 0 0cm-1处的峰强 ;130 0cm-1的峰强明显增加。慢性萎缩性胃炎呈现出部分胃癌的光谱特征。这一结果表明 ,应用FTIR可以对胃镜下活检的小块组织进行鉴别诊断。
A total of 184 specimens from gastroscopy were studied using Fourier transform infrared(FTIR) spectroscopy. The spectra of small-sized gastric endoscope samples with high quality were measured using the modified FTIR spectrometer with a MCT detector. The results show that the spectra of chronic superficial gastritis are similar to those of the normal block tissue in our previous study. But there are significant differences in band location and relative intensity between the spectra of chronic superficial gastritis and those of normal gastric tissues. Similarly, the differences exist in the spectra of chronic atrophic gastritis and those of malignant gastric tissues. In addition, the subtraction technique can provide more information to identify well the gastric samples of chronic atrophic gastritis, superficial gastritis and gastric cancer from endoscope the detection. These results indicate that FTIR spectroscopy exhibits potential to diagnose the gastric samples from gastroscopy.
出处
《光谱学与光谱分析》
SCIE
EI
CAS
CSCD
北大核心
2004年第8期933-935,共3页
Spectroscopy and Spectral Analysis
基金
国家自然科学基金 (30 371 60 4 )
国家重点基础研究发展规划(2 0 0 2CCA0 1 90 0 )
教育部博士点基金
陕西省科学技术研究发展计划项目(2 0 0 3K1 0 G37)资助
