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苯基哌嗪衍生物的NMR波谱研究 被引量：3

A NMR STUDY OF PHENYLPIPERAZINE DERIVATIVES
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摘要 通过~1H NMR、^(13)C NMR、及 HMBC、HSQC、~1H-~1H DQFCOSY等 2D NMR方法对新合成的 10个苯基哌嗪衍生物类抗高血压药物进行结构鉴定,并对这些化合物的~1H NMR和^(13)C NMR信号进行了全归属。初步探讨了取代基对分子^(13)C化学位移的影响。 Abstract: Having the potential of being used as α_1-adrenoceptor antagonist and new anti- hypertensive drugs, ten phenylpiperazine derivatives were synthesized, and their struc- tures were determined by ~1H NMR, ^(13)C NMR, HMBC, HSQC and ~1H-~1H DQF-COSY. The ~1H and ^(13)C chemical shifts of these compounds were assigned. The relationship be- tween the substitute groups and the ^(13)C chemical shifts was discussed.
作者 肖志会 袁牧 黄建设 吴军
机构地区 中国科学院南海海洋研究所广东省海洋药物重点实验室 中国科学院天然产物化学重点实验室
出处 《波谱学杂志》 CAS CSCD 北大核心 2004年第3期365-369,共5页 Chinese Journal of Magnetic Resonance
基金 国家自然科学基金(30060087)
关键词 核磁共振 归属 化学位移 苯基哌嗪 结构鉴定 NMR assignments chemical shift phenylpiperazine
分类号 O641 [理学—物理化学]
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参考文献8

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二级参考文献3

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共引文献6

同被引文献28

  • 1屈凌波,梁瑞玲,程森祥.苄基哌嗪衍生物的量子化学计算和^(13)C NMR化学位移相关性研究[J].郑州轻工业学院学报（自然科学版）,2006,21(2):6-9. 被引量：2
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引证文献3

二级引证文献11

波谱学杂志
2004年 第3期

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