摘要
通过~1H NMR、^(13)C NMR、及 HMBC、HSQC、~1H-~1H DQFCOSY等 2D NMR方法对新合成的 10个苯基哌嗪衍生物类抗高血压药物进行结构鉴定,并对这些化合物的~1H NMR和^(13)C NMR信号进行了全归属。初步探讨了取代基对分子^(13)C化学位移的影响。
Abstract: Having the potential of being used as α_1-adrenoceptor antagonist and new anti-
hypertensive drugs, ten phenylpiperazine derivatives were synthesized, and their struc-
tures were determined by ~1H NMR, ^(13)C NMR, HMBC, HSQC and ~1H-~1H DQF-COSY.
The ~1H and ^(13)C chemical shifts of these compounds were assigned. The relationship be-
tween the substitute groups and the ^(13)C chemical shifts was discussed.
出处
《波谱学杂志》
CAS
CSCD
北大核心
2004年第3期365-369,共5页
Chinese Journal of Magnetic Resonance
基金
国家自然科学基金(30060087)