离子—分子反应及其在质谱分析中的应用

Ion/Molecule Association Reactions and Their Applications to Mass Spectrometry

利用离子—分子反应 ,不仅可以提供分子离子峰 ,而且可以提高检测的灵敏度 ,了解分子的结构特征。本文根据离子—分子反应的机理 ,介绍了金属离子的亲和力的测定方法和金属离子在化合物上的加合位点 ,并阐述了离子—分子反应在化学电离质谱 ( CI-MS)、碱金属离子化学电离质谱 ( ACI-MS)、电喷雾电离质谱 ( ESI-MS)、快原子轰击质谱 ( FAB-MS)、以及基质辅助激光解吸电离质谱 ( MALDI-MS)

This review covers the reaction mechanisms and applications of ion/molecule association reactions for solving increasingly complex analytical problems. Because these reactions are frequently fast and efficient, the use of ion/molecule reactions provides a diverse frontier for extending the boundaries of mass spectrometry. Adduct ions from ion/molecule reactions may provide the molecule mass information for those nonvolatile, labile compounds, improve the detection sensitivity, and particular product ions may afford key diagnostic information for structure identification. In addition, alkali metal ion affinities and coordination of alkali metal ion to compounds are introduced.