摘要
通过给予日本大耳白兔高脂饮食，同时给予抗氧化维生素（维生素E、维生素C及β胡萝卜素），用酶标免疫法（ELISA）测定免血清氧化低密度脂蛋白（oxLDL）水平。结果发现，取抗氧化维生素组oxLDL水平明显降低，且兔主动脉动脉粥样硬化（As）斑块形成减轻，泡沫细胞减少，平滑肌细胞增生减轻。探讨了As形成的机制，从一个侧面为As的防治提供了理论依据。
In order to study the inhibitory effects of antioxidant vitamins on serum (low oxidative density lipoproteins, oxLDL) and experimental atherosclerosis in rabbits, 20 rabbits were fed on cholesterol rich diet and antioxidant vitamins (vitamin E, vitamin C and β carotene) for 12 weeks. oxLDL were tested by ELISA at the beginning of experiment and after 4 weeks 8 weeks. ResuIts The results showed that supplement of antioxidant vitamins can decrease the oxLDL level significantly and inhibited development of atherosclerosis lesion around aorta in rabbits.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1997年第6期451-455,共5页
Acta Academiae Medicinae Sinicae
基金
卫生部科研基金!94-1-032
