急性中度等容血液稀释对维库溴铵药代动力学的影响

Effect of Acute Moderate Isovolumic Hemodilution on the Pharmacokinetics of Vecuronium

研究观察了急性中度等容血液稀释对维库澳馁药代动力学的影响。26例ASAI级施择期整形外科手术的患者，平均分成对照组和血液稀释组。静注维库澳铵100μg/kg后，用荧光法测定血药浓度。并用3P87药代动力学程序进行计算。维库溴铵的体内过程能用三室开放模型完整描述。与对照组相比，血液稀释组患者的中央室分布容积（Vc）和稳态分布容积（Vdss）明显增大，排泄半衰期（T1／2β）明显延长，而快分布相半衰期（T1／2π）、分布半衰期（T1／2α）、药物转运速车常数（K12、K21、K13、K31、K10）、曲线下面积（AUC）、平均残留时间（MRT）和血浆清除率（Cl）在两组间差别不明显。

To determine the effect of acute moderate isovolemic hemodi1ution on pharmacokinetics of vecuronium. Methods Twenty-six adult patients,ASA grade I, undergoing elective plastic surgery, were randomly divided equally into the control and hemodilution group. The blood samples were taken for 5 hours following intravenous bolus of 100μg/kg of vecuronium in two groups. The plasma concentrations of vecuronium were determined with an improved fluorometry and the pharmacokinetic parameters were obtained by fitting the data with a 3P87program. Results The disposition of vecuronium can be best described by a three compartment open model. As comparison with the control group,the values of Vc and Vdss ln hemodilution group were greater than that in the control,while T1/2β was markedly prolonged in this group. There were no significant differences in T1/2π, T1/2α, K12, K21, K13, K31, K10, MRT, AUC, and Cl between the two groups. Conclusion Acute moderate isovolemic hemodilution could change the pharmacokinetics of vecurinium,particularly in distribution and elimination phases.