摘要
本文通过启动、促成和作用方式的研究,较全面地详述了林丹对大、小白鼠的致癌危险性.大量结果证实,林丹对大白鼠既不能诱导肿瘤,亦无致癌作用,对小白鼠则有不同结果.有试验表明,当林丹使用剂量大于160mg/kg饲料时,有可能导致增生瘤或肝细胞腺瘤.如此高的剂量已超出了可忍受限度.机制研究表明林丹对小白鼠的致癌作用系非遗传机制.
The paper describes in detail the carcinogenic potential of lindane to rats and mice, according to research on initiation, promotion and action-mode. The results of action-mode research reveal that tumorigenic effect of lindane in mice results from non-genetic mechanisms.
