支原体感染与低出生体重儿的红霉素干预实验

Erythromycine clinical intervention for the study of relationship between mycoplasma infection of pregnant women and low birth weight

目的 :探索孕妇生殖道支原体感染与低出生体重儿的病因学关系。方法 :经产前检查支原体阳性孕妇 4 88例 ,按实验分组方法随机分成红霉素干预组和非干预组 ,比较两组间孕妇支原体感染阴转率、母婴传播率和低出生体重儿的发生率。结果 :红霉素干预组解脲脲原体 (Ureaplasmaurealyticum ,Uu)的阴转率和母婴传播率低于非干预组 ,差异有显著性意义 (P <0 .0 5 ) ,而人型支原体 (Mycoplasmahoninis,Mh)的阴转率及母婴传播率在组间差异无显著性意义。干预组中低出生体重儿的发生率显著低于非干预组 (P <0 .0 5 )。结论 :红霉素干预措施能有效地降低孕妇Uu感染 ,阻断其母婴传播 ,降低低出生体重儿发生率。

Objective:To explore the hypothesis of pathogenic relationship between urogenital mycoplasma infection and low birth weight.Methods:488 mycoplasma positive pregnant women that were detected by culture method were randomly divided into Erythromycine intervention group and non intervention group according to trial grouping method. The comparison of mycoplasma changing negativity rate、vertical transmission rate and low birth weight incidence were made between groups.Results:Ureaplasma urealyticum changing negativity rate and vertical transmission rate in intervention group were significantly lower than in non intervention group(P<0.05).However,there was not significant difference in mycoplasma hominis changing negativity rate and vertical transmission rate between groups. The incidence of Low birth weight in intervention group was significantly lower than in non intervention group (P<0.05).Conclusion:Erythromycine is effective in controlling ureaplasma urealyticum infection of pregnant women、cutting off vertical transmission passway and lowering the incidence of low birth weight against ureaplasma urealyticum.