情绪应激体液免疫调节作用的影响因素

TWO KINDS OF CONDITIONS INFLUENCE THE HUMORAL IMMUNOMODULATION INDUCED BY EMOTIONAL STRESS

以给予经定时喂水训练大鼠空瓶刺激为情绪性心理应激源 ,研究了应激源给予的频率及抗原免疫前或后给予应激刺激等因素对此情绪应激体液免疫调节作用的影响。结果表明 ,特异性抗原OVA免疫前 3次 ,每次 30分钟的情绪应激刺激不影响大鼠的抗OVA抗体水平和脾脏指数 ;抗原免疫后 ,同样频率和持续时间的情绪应激能一定程度地降低体液免疫功能 ;而抗原免疫后 14次 ,每次 10分钟的情绪应激刺激则显著降低大鼠的抗OVA抗体水平和脾脏指数。该研究证实 ,抗原免疫后、反复多次的情绪应激刺激能显著抑制大鼠的原发性体液免疫功能。

The effect of frequency of emotional stressor presenting and the order in which emotional stress and antigen immunization occurred on the humoral immunomodulati on of emotional stress was studied in adult male Wistar rats. Emotional stress w as induced by randomly giving empty water bottles to rats trained to drink water at two set times each day,the specific antigen Ovalbumin (OVA) was used to immu nize the rats. Results showed that before the antigen immunization,three times e motional stress,30 minutes each time,did not influence the level of anti OV A IgG antibody and spleen index (the primary humoral immunity);however,after ant igen immunnization,the same emotional stress decreased the level of antibody and spleen index;and ,14 times emotional stress after antigen immunization,10 minut es each time,suppressed significantly the primary humoral immune function. T aken together,these findings demonstrated that emotional stress can modulate the humoral immune response,but the effect is dependent upon the severity of emotion al stress and the order in which emotional stress and antigen immunization occur red,14 times emotional stress after antigen immunization suppressed the primary humoral immunity.