早老性痴呆病人早期记忆损害的检测方法

A METHOD OF EXAMINING THE EARLY MEMORY IMPAIRMENTS OF ALZHEIMER'S DISEASE

采用词语延迟回忆、记忆广度和双任务工作记忆测验 ,研究可能用于检测 (Alzheimer’sdisease ,AD)早期记忆损害的方法。共有 4组被试 :两个正常年轻人组、一个正常老年人组、一个很可能患早老性痴呆病人 (ProbableAD ,PAD)组。结果表明 :(1)正常年轻人和正常老年人的词语延迟回忆保持率没有显著差异 ,而PAD患者表现出明显受损 ;(2 )两个正常年轻人组的双任务工作记忆成绩也没有显著不同 ,与之相比 ,正常老年人组有一定程度的降低 ,而PAD患者表现出更大程度的损害 ;(3) 4组被试的记忆广度都不相同。这些结果提示 ,词语延迟回忆和双任务工作记忆测验可能能够用于检测AD早期的记忆损害。

The method of examining the early memory impairments of Alzheimer's di sease was investigated with word delayed recall, memory span, and dual task wor k ing memory tests. Four subject groups, including two normal youth groups, a norm al elder group, and a probable AD group, participated in this study. The results showed that: (1) the word delayed recall probability had no significant differe nce between two youth groups and between the young and the elderly subjects, how ever, it was significantly damaged in the PAD subjects; (2) two groups of young subjects had similar performance in the dual task working memory tests, and the elderly subjects showed some decrease in the performance, but the PAD had more i mpairment in this task; (3) all groups of subjects were different from each othe r in the memory span task. These results indicated that the word delayed recall and the dual task working memory tests may be useful in examining the early mem ory impairments of Alzheimer's disease.