环磷酰胺冲击治疗顽固性肾病综合征的护理

Treatment of intractable nephrapathy syndrom by cyclophophomide therapy

目的 :探讨环磷酰胺冲击治疗顽固性肾病综合征的护理措施。方法 :对照组 33例患者 ,常规口服强的松 1mg/kg ,连用 1～ 2月 ,病情稳定后 ,强的松逐渐减量。治疗组 37例患者在口服强的松 (1mg/kg)的同时 ,将环磷酰胺 8～ 12mg/kg加入生理盐水 2 5 0ml中静滴 ,2h内滴完 ,1次 /d× 2d。每月冲击 1～ 2次 ,连用 3个月。以后视病情间隔 2～ 3个月冲击治疗 1～ 2次 ,环磷酰胺总量 6～ 8g。两组在治疗的同时 ,对照组予以常规护理 ,治疗组采用自定的护理措施 ,包括一系列的心理护理、临床观察、出院指导等。结果 :37例中显效 33例 (89 2 % ) ,有效 3例 (8 1% ) ,无效 1例 ,总有效率97 3%。与对照组比较 ,显效率及总有效率差异有显著性。治疗组患者均依从治疗 ,无 1例出现消极、埋怨情绪 ,未见严重不良反应发生。结论 :环磷酰胺冲击治疗顽固性肾病综合征 ,采用系列科学有效的护理措施 ,患者依从性好 ,疗效可靠 。

Objective:To explore for nursing measures about treatment of intractable nephropathy by cyclophosphamide therapy.Method:In control group,33 patients received oral deltacortone 1mg/kg for 1～2 months then at less dosage after stablization of condition.In experiment group cyclophosphamide ivdrip within 2hrs,8～12mg/kg in 250ml NS,1～2 times/month for 3 months,in addition to the above,experiment group received psychological nursing.Clinical observation,discharging induction.Result:33 in 37 cases show extremly effective(89.2%),3 cases effective(8.1%),1 case without any effect,all cases in experiment group were all compliant to therapy,without any depression complainment no serious complication.Conclusion:Cydophosphamide therapy can treat intractable nephrophathy syndrom effectively with the help of relative nursing patients show good compliance without any serious complication.