氯氮平对精神分裂症患者血浆及脑脊液中白细胞介素6的影响

Effects of clozapine on interleukin-6 in plasma and cerebrospinal fluid of schizophrenics

目的:研究氯氮平治疗精神分裂症患者前后血浆及脑脊液中白细胞介素6(IL-6)的变化,以及精神分裂症患者的免疫状态和抗精神病药物对免疫学指标的影响。方法:实验组为新乡医学院第二附属医院住院的符合中国精神疾病诊断标准及分类方案第三版精神分裂症偏执型诊断标准的首发精神分裂症患者(n=30),入组后单独应用氯氮平治疗犤氯氮平最大剂量150～400mg/d,平均剂量(290±70)mg/d犦;对照组为患者家属及非精神疾患的轻微脑损伤并脑脊液检查正常患者(n=20)。采用酶联免疫吸附法测定对照组和实验组血浆及脑脊液中IL-6的水平,并进行组间比较。结果:实验组在治疗前血浆及脑脊液IL-6水平分别为(46.73±23.27)和(10.41±8.40)ng/L,比对照组显著增高,差异有显著性意义(t=2.23,P<0.05);实验组治疗6周症状缓解后,血浆IL-6水平犤(49.34±25.24)ng/L犦较对照组显著增高,差异有显著性意义(P<0.05)。结论:精神分裂症患者存在免疫功能紊乱,氯氮平治疗可改善其免疫功能。

AIM:To evaluate the alterations of interleukin 6(IL 6) in the plasma and cerebrospinal fluid of schizophrenics treated by clozapine,and the effect of immune status and anti psychiatric drug on immunologic index. METHODS:A total of 30 schizophrenic inpatients who fulfilled the third edition of the Chinese Classification and Diagnostic Criteria of Mental Disease(CCMD 3) for paranoid schizophrenia were enrolled from the Second Affiliated Hospital of Xinxiang Medical College as experimental group and treated only by clozapine[max dosage 150 to 400 mg per day,mean dosage(290±70) mg per day].Relatives and non mental disease patients with light brain damage but normal cerebrospinal fluid were enrolled as control group(n=20).The contents of IL 6 in plasma and cerebrospinal fluid were measured by enzyme linked immunosorbant assay(ELISA) between two groups. RESULTS:Before treatment,in the experimental group,the levels of IL 6 in plasma and cerebrospinal fluid before treatment were(46.73±23.27) and(10.41±8.40) respectively,which were significantly higher than that in the control group(t=2.23,P< 0.05).Six weeks after treatment,the levels of IL 6[(49.34±25.24) ng/L] in the plasma were significantly higher in the experimental group than in the control group (P< 0.05). CONCLUSION:Schizophrenic patients have immune dysfunction,which can be treated by clozapine.