莱菔硫烷与肿瘤

Study on the relationship between sulforaphane and cancers

莱菔硫烷 (SFN)是十字花科植物绿花椰菜中所含的一种植物化学物 -异硫氰酸盐。SFN是一种Ⅱ相酶的诱导剂 ,可预防许多化学致癌物诱导的DNA损伤和多种肿瘤的发生。SFN可诱导肿瘤细胞凋亡、使细胞生长周期停止、抑制多种化学致癌物的代谢活化和抑制炎症 ,目前认为SFN是潜在的肿瘤治疗药物。

Sulforaphane is an isothiocyanate isolated from cruciferous vegetable broccoli as the major phase Ⅱ enzyme inducer. It has shown chemopreventive activities on DNA damage and cancers, leading to cancer cells apoptosis, cell growth arrest, inhibition of inflammation and modulation the metabolism of carcinogens. So it was considered as a potent cancer therapeutic drug. The mechanisms of SFN were presented in this paper.